Whether new to motherhood or a seasoned parent, bringing a precious new baby into the world can often be overshadowed by feelings of sadness, isolation, and exhaustion. It’s true that nearly all women experience a brief period known as the “baby blues” — a mild and temporary form of depression that can include mood swings, crying spells, anxiety, difficulty sleeping, and feelings of being overwhelmed — shortly after childbirth. But if those feelings persist or get worse, they could lead to postpartum depression (PPD), which can be serious if left unaddressed.

Most symptoms of PPD — prolonged depression, tearfulness, irritability, poor sleep (beyond lack of sleep that accompanies the newborn period), and even suicidal thoughts — arise within the first few weeks after giving birth, but women can be diagnosed with the condition up to a year postpartum.

READ: The Reality of Postpartum Depression

When it comes to this often silent struggle, finding the right support and treatment is essential. One option that has shown promise in helping women reclaim their well-being after childbirth is Zurzuvae, a fairly new, FDA-approved medication that is designed to treat postpartum depression.

What is Zurzuvae?

Approved by the FDA in 2023, Zurzuvae (generic name: zuranolone) is a short-term oral medication specifically designed for the rapid treatment of postpartum depression. Unlike traditional antidepressants, which can take weeks to show effects, Zurzuvae works quickly — often within just a few days. This makes it a welcome option for women who need immediate support as they navigate the challenges of having a new baby. Because it is rapid, yet short-term, it can help bridge the gap during the time period before the benefits of an SSRI are felt.

READ: Get Postpartum Support at Baptist Health’s ‘The Motherhood Space’

How does Zurzuvae work?

After giving birth, women experience a whirlwind of emotions, hormones, and physical changes. Zurzuvae works by targeting the brain’s GABA-A receptors that are responsible for mood regulation and acts as a synthetic form of allopregnanolone — a naturally occurring neurosteroid made from progesterone that enhances GABA-A function.

Zurzuvae is taken orally once per day for 14 days, and relief may be felt as early as three days into the treatment. In clinical trials, women continued to feel relief for up to four weeks after they finished taking the medication.

Are there any side effects when taking Zurzuvae?

Side effects from Zurzuvae are typically mild but may include decreased awareness and alertness, which can affect your ability to drive safely — this is why those taking Zurzuvae should wait to drive for at least 12 hours after taking the dose. Additional side effects may include sleepiness, drowsiness, confusion, dizziness, trouble walking, diarrhea, and/or a risk of urinary tract infection. Always tell your healthcare provider if you develop any of these symptoms or if they get worse during treatment.

If nursing, know that Zurzuvae can pass into breast milk, so it is important to speak with your healthcare provider about the risks and benefits of taking the medication while breastfeeding and about the best way to feed your baby during the 14-day treatment course.

Is Zurzuvae for everyone?

Like any medication, Zurzuvae isn’t a one-size-fits-all solution. It’s designed specifically for women with postpartum depression, and it is important to have a thorough discussion of medical history, risks, and benefits with your provider before starting treatment.

If you would like to learn more about Zurzuvae and its treatment of PPD, call Beaches OBGYN at (904) 241-9775 or text (904) 441-6725 to make an appointment with your provider.